Cristiano Ronaldo is scheduled to play for Al-Nassr in the encounter. The game will be held at Riyadh's Prince Faisal bin Fahd Stadium.
Al-Nassr presently sits second in the league rankings, while Al-Shabab is fifth. The two sides have a long history of enmity, with Al-Nassr winning their most recent match 2-1.
With a recent streak of victories, Al-Nassr will be seeking to retain their momentum.